MED4

MED4

Identifiers

Aliases
MED4, ARC36, DRIP36, HSPC126, TRAP36, VDRIP, mediator complex subunit 4

External IDs
MGI: 1914631 HomoloGene: 8568 GeneCards: MED4

Gene ontology

Molecular function
• thyroid hormone receptor binding
• protein binding
• transcription cofactor activity
• ligand-dependent nuclear receptor transcription coactivator activity
• vitamin D receptor binding
• receptor activity
• RNA polymerase II transcription cofactor activity

Cellular component
• core mediator complex
• membrane
• nucleus
• mediator complex
• nucleoplasm

Biological process
• regulation of transcription from RNA polymerase II promoter
• positive regulation of transcription, DNA-templated
• androgen receptor signaling pathway
• intracellular steroid hormone receptor signaling pathway
• regulation of transcription, DNA-templated
• transcription from RNA polymerase II promoter
• transcription, DNA-templated
• transcription initiation from RNA polymerase II promoter

Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species
Human
Mouse

Entrez

29079

67381

Ensembl

ENSG00000136146

ENSMUSG00000022109

UniProt

Q9NPJ6

Q9CQA5

RefSeq (mRNA)

NM_014166
NM_001270629

NM_026119

RefSeq (protein)

NP_001257558
NP_054885

NP_080395.1
NP_080395

Location (UCSC)
Chr 13: 48.05 – 48.1 Mb
Chr 14: 73.51 – 73.52 Mb

PubMed search
[1]
[2]

Wikidata

View/Edit Human
View/Edit Mouse

Med4

Identifiers

Symbol
Med4

Pfam
PF10018

InterPro
IPR019258

Available protein structures:

Pfam
structures

PDB
RCSB PDB; PDBe; PDBj

PDBsum
structure summary

Mediator of RNA polymerase II transcription subunit 4 also known as mediator complex subunit 4 (MED4), a component of Mediator or vitamin D3 receptor-interacting protein complex 36 kDa component (DRIP36) is a protein that in humans is encoded by the MED4 gene.[3][4][5]

Contents

1 Function
2 Interactions
3 References
4 Further reading

Function[edit]
The protein encoded by this gene is a component of the vitamin D receptor-interacting protein (DRIP) complex which functions as a nuclear receptor coactivator. The DRIP complex is capable of activating nuclear receptors in a ligand-dependent manner.[4]
Interactions[edit]
MED4 has been shown to interact with MED25.[6]
References[edit]

^ “Human PubMed Ref